|
KMID : 0043320100330111747
|
|
Archives of Pharmacal Research
2010 Volume.33 No. 11 p.1747 ~ p.1751
|
|
|
Inhibitory activities of anthraquinones from Rubia akane on phosphatase regenerating liver-3
|
|
Moon Mi-Kyeong
Han Young-Min
Lee Yu-Jin
Lee Lan-Hee
Yang Jae-Heon
Kwon Byoung-Mog
Kim Dae-Keun
|
|
|
Abstract
|
|
|
|
The methanolic extract of the roots of Rubia akane (Rubiaceae) was found to show inhibitory activity on phosphatase of regenerating liver-3 (PRL-3). Bioassay-guided fractionation of the methanolic extract resulted in the isolation of two anthraquinone compounds, 2-methyl-1,3,6-trihydroxy-9,10-anthraquinone-3-O-(6′-O-acetyl)-α-rhamnosyl(1→2)-β-glucoside and 2-methyl-1,3,6-trihydroxy-9,10-anthraquinone, as inhibitors on PRL-3. These compounds inhibited PRL-3 in a dose-dependent manner with IC50 values of 5.2 and 1.3 μg/mL, respectively.
|
|
|
KEYWORD
|
|
|
Rubia akane, Rubiaceae, Anthraquinone, PRL-3
|
|
|
FullTexts / Linksout information
|
|
|
|
|
|
Listed journal information
|
|
  
|